Goose Creek is a city in Berkeley County in the U.S. state of South Carolina. The population was 35,938 at the 2010 census. Most of the Naval Weapons Station Charleston is in Goose Creek. As defined by the U.S. Office of Management and Budget, and used by the U.S. Census Bureau for statistical purposes only, Goose Creek is included within the Charleston-North Charleston-Summerville metropolitan area and the Charleston-North Charleston Urbanized Area.

Although the city of Goose Creek was established in 1961, its history dates back many centuries. In early colonial times the term "Goose Creek men" was used for a group of colonists, mostly settled a few miles north of Charleston near a stream called Goose Creek, a tributary of the Cooper River. The Goose Creek men became leaders of the early Indian trade, and by the 1690s many held important offices in the colonial government. At first the Goose Creek men dealt mainly in Indian slaves, while later the deerskin trade dominated. Several colonial governors were Goose Creek men, such as James Moore and Robert Daniell.

The Otranto Plantation Indigo Vats and St. James Church are listed on the National Register of Historic Places.